Tadalafil

TRADE NAMES: Cialis, Cidala, Adcirca

 CLASSIFICATION : Phosphodiesterase inhibitors (PDA inhibitors)

 ROUTE OF ADMINISTRATION: Oral

 BIOAVAILABILITY: Varies

 ELIMINATION HALF-LIFE : 17.5 hours

 The drug Tadalafil was discovered by Glaxo Wellcome in the year 1991, presently known as GlaxoSmithKline under the cooperation between Glaxo and ICOS. The drug became medically available from the year 1998. It was recommended as a medication for men suffering from Erectile Dysfunction and impotence men and the drug, not only helps in sexual stimulation but the steroid will also help in increasing the blood flow to the penis and gradually enable in getting and keeping an erection. Later the drug became more industrious and it was started to be prescribed for patients suffering from Pulmonary Artery Hypertension and Benign Prostatic Hyperplasia. Tadalafil was approved in the year 2009 as a medication for people suffering from Pulmonary Artery Hypertension. The drug Tadalafil was approved by the US FDA on 6 October 2011 for use commercially and legally for Benign Prostatic Hyperplasia.

Taking Tadalafil once is recommended for Erectile Dysfunction. The Drug acts by relaxing the smooth muscles of the prostate gland and the bladder and helps in lessening the difficulties faced by the patients in the onset of the discharge of urine, vulnerable stream, and the necessity to urinate continually or gently. 

The recommended dosage for individuals is 10 mg before the sexual activity and the effect can last for 36 hours. The dosage of 10 mg daily is recommended for treating the symptoms of Benign Prostatic Hyperplasia. 40 my daily is recommended in patients suffering from Pulmonary Artery Hypertension.

 The most common side effects of the drug include;

• Headache
• Stomach discomfort or trauma
• Indigestion
• Burping
• Acid reflux
• Back pain
• Muscle aches
• Flushing, stuffy and runny nose

 Unusual and serious side effects include:

• Damage to the penis
• Vision problems
• Hearing loss

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